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Title:Molecular & Cellular Targets for Anti-Epileptic Drugs
Series:(Current Problems in Epilepsy, Volume 12)
Author:G Avanzini, G Regesta, P Tanganelli & M Avoli (eds)
ISBN:086196554X : 9780861965540
Illustrations:tables & charts
Format:Hardback
Size:175x245mm
Pages:266
Weight: .698 Kg.
Published:John Libbey Eurotext - January 1997
List Price: 110.99 Pounds Sterling
Availability:In Print
Subjects:Neurology & clinical neurophysiology: Pharmacology


A new phase of anti-epileptic drugs (AEDs) investigation has begun in which new drugs can be designed to target specific epileptogenic mechanisms. A rational approach to therapy today requires not only a full awareness of phamacokinetics of AEDs but also a thorough knowledge of their molecular targets and of their influence on excitatory and inhibitory mechanisms in the brain. This book provides a multi-author systematic look at this subject, from neurobiological bases to clinical applications. It includes four sections dealing with fundamental aspects of cortical excitability, models of epileptic disorders, targets for anti-epileptic drugs and rational approaches to therapy. Each chapter provides a review of a specific topic prepared by well known scientists active in the field, introducing their most recent results in a concise and comprehensive form.