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Title:Immune-mediated Disorders of the Central Nervous System in Children
Series:(Mariani Foundation Paediatric Neurology, Volume 10)
Author:L Angelini, M Bardare & A Martini (eds)
ISBN:0861966317 : 9780861966318
Illustrations:b/w illus & tables
Size:175x245mm
Pages:284
Weight: .86 Kg.
Published:John Libbey Eurotext - January 2002
List Price: 68.5 Pounds Sterling
Availability:In Print
Subjects:Neurology & clinical neurophysiology: Paediatric medicine


Immunopathogenesis has recently been receiving increased interest from researchers, leading to a better understanding of the mechanisms of neurological disorders and consequently to new diagnostic approaches and therapeutic perspectives. Clinical neuroimmunology in childhood is the focus of the present volume. This book is divided into three sections. The first part deals with the relationship between the immune and the nervous systems, from antigen presentation to autoimmunity and its role in neurological disease. In the second part, the nosography of immune-mediated neurological diseases in children is described, including those primarily involving the central nervous system and those secondary to systemic immunological disorders. The last part of the book is devoted to diagnostic and therapeutic criteria.

Molecular mimicry and autoimmunity; lnteraction between immune system and central nervous system: Peculiar aspects and relevance for the pathogenesis of immune-mediated diseases of the central nervous system; Inflammatory, immune-mediated disorders of the central nervous system; Multiple sclerosis: a disease of many faces and many ages; Multiple sclerosis in childhood: clinical aspects; Acute disseminated encephalomyelitis; Opsoclonus-myoclonus syndrome in children; Rasmussen's syndrome; Rheumatic Fever and its neurologic features; Neurological manifestations of rheumatic fever; Systemic lupus erythematosus; Neurological involvement in systemic lupus erythematosus; Pathogenetic mechanisms of the antiphospholipid syndrome; The antiphospholipid syndrome in paediatrics: clinical aspects; Neurologic disorders associated with antiphospholipid antibodies; Endothelial cell role in the pathogenesis of the antiphospholipid syndrome; Central nervous system vasculitis; Neurological impairment in systemic vasculitides; Diagnostic and prognostic role of autoantibodies in connective tissue diseases; Immune-mediated disorders of the CNS a paediatric age: neuroradiological findings; Use of magnetisation transfers imagining to study multiple sclerosis and other immune-mediated disorders of the CNS; Corticosteroids; Intravenous immunoglobulins; Cytotoxic and noncytotosic immunosuppressive agents; Immunomodulation by plasmapheresis and immunoadsorption for autoimmune neurological disorders in children; New perspectives in the treatment of childhood rheumatic diseases; Interferon beta and glatiramer acetate in multiple sclerosis.