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| Title: | Creatine Kinase
|
| Author: | Christian Vial (ed) |
| ISBN: | 1594547157 : 9781594547157 |
| Illustrations: | tables & charts |
| Format: | Hardback |
| Size: | 180x260mm |
| Pages: | 281 |
| Weight: | .83 Kg. |
| Published: | Nova Science Publishers - September 2006 |
| List Price: | 73.5 Pounds Sterling |
| Availability: | In Print |
| Subjects: | Enzymology |
Creatine kinases and arginine kinases are an historical model in enzymology. They belong to the large family of phosphagen kinases which transfer a phosphoryl group from ATP to a nitrogen atom within a guanidinium group to form that was called by the early muscle physiologists a 'phosphagen'. These compounds and the enzymes that catalyse their formation and use are present in cells with important and rapidly fluctuating energy requirements.
Preface; Evolution and Divergence of Creatine Kinases; Using site-directed mutagenesis to elucidate structure and function in creatine kinase; The Structural Enzymology of Arginine Kinase and its Implications for Creatine Kinase; Creatine kinase folding and unfolding; Molecular structure and function of mitochondrial creatine kinase; The interaction of mitochondrial creatine kinase with the outer membrane pore (VDAC), and the adenine nucleotide translocator (ANT) has important functions in regulation of energy metabolism and apoptosis; Adenylate kinase and creatine kinase phosphotransfer in the regulation of mitochondrial respiration and cellular energetic efficiency; The Creatine Kinase Isoenzymes in Organised Metabolic Networks and Regulation of Cellular Respiration: A New Role for Maxwell's Demon; Index.
