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| Title: | In Silico Genomics & Proteomics
: Functional Annotation of Genomes & Proteins |
| Author: | Nicola Mulder & Rolf Apweiler (eds) |
| ISBN: | 1594549958 : 9781594549953 |
| Illustrations: | tables & charts |
| Format: | Hardback |
| Size: | 180x260mm |
| Pages: | 226 |
| Weight: | .704 Kg. |
| Published: | Nova Science Publishers - December 2006 |
| List Price: | 59.5 Pounds Sterling |
| Availability: | In Print |
| Subjects: | BIOLOGY; LIFE SCIENCES |
The advancement of DNA sequencing technologies has resulted in a movement away from the single gene, and towards a whole genome focus. Previously DNA sequencing was expensive, slow and tedious, but new technologies have been developed that facilitate the relatively cheap and rapid generation of raw sequence from whole bacterial genomes. The sequencing of the human genome was also accelerated in the final phases as a result of new sequencing methods. However, generating the raw sequence is just the start, and tools are required to convert it into useful biological knowledge. This book highlights the new advances in DNA sequencing, and summarises the process of genome and protein annotation. The book also describes the tools required to achieve this, and provide examples within the context of specific genomes.
Genomics and the genome era; Sequence clustering as a method of protein functional annotation; Function prediction with protein signatures and InterPro; The Gene Ontology Annotation (GOA) database; Curator driven protein sequence analysis and annotation; Automated annotation of proteins; Guilt by association: using protein interactions and expression patterns to predict protein function; Artemis and ACT: DNA sequence viewing, annotation and comparison tools; Ensembl’s annotation pipeline and its use in eukaryotic genomes; Genome annotation and viewing in VEGA; The PEDANT genome database; Microbial genomes at NCBI; PlasmoDB: the Plasmodium genomics and functional genomics resource; Integr8: Navigating Genome Reviews and the Proteome Analysis Database; Index.
