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| Title: | Cancer Drug Resistance Research Perspectives
|
| Author: | Liman S Torres (ed) |
| ISBN: | 1600215726 : 9781600215728 |
| Illustrations: | tables & charts |
| Format: | Hardback |
| Size: | 180x260mm |
| Pages: | 223 |
| Weight: | .706 Kg. |
| Published: | Nova Science Publishers - September 2007 |
| List Price: | 85.99 Pounds Sterling |
| Availability: | In Print |
| Subjects: | Medical research: Oncology: Pharmacology |
One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field.
Preface; Expert Commentary; New Research Communications on Cancer Drug Resistance; Resistance to Apoptosis: A mechanism associated with the sensitivity of head and neck cancers to anti-cancer drug therapy; Mitotic checkpoint and its role in chemodrug sensitivity in human cancer; New Research Communications on Cancer Drug Resistance, Assessment of cancer drug resistance with nuclear medicine images; Epithelial-Mesenchymal Transition (EMT) and its involvement in Acquired Endocrine Resistance in Breast Cancer Molecular Mechanisms of Cisplatin Resistance in Prostate Cancer Cells; Early resistance to induction chemotherapy assessed by residual blasts in bone marrow and/or peripheral blood at day 8 is associated with unfavourable outcomes in adult acute lymphoblastic leukaemia; Spontaneous canine melanoma derived spheriods display individual multicellular resistance patterns to suicide gene and chemotherapy; Drug resistance to rapamycin through elevated phospholipase D activity; Stromal fibroblasts as determinants of the efficacy of anticancer therapy; Overcoming chemoresistance in ovarian cancers by ultrasound; Arsenic therapy of acute promyelocytic leukemia (APL): Speciation of Arsenic Metabolites in a treated APL; Overcoming Ovarian Cancer Drug Resistance with Phytochemicals and Other Compounds; Ascorbic Acid enhances the Cytotoxic Action of Teraphthal on Lympholeukosis P388 Cells.
