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| Title: | Molecular Aspects of G Protein-Coupled Receptors
: Interacting Proteins & Function |
| Author: | Franciso Ciruela & Rafael Lujan (eds) |
| ISBN: | 1600219152 : 9781600219153 |
| Illustrations: | tables & charts |
| Format: | Hardback |
| Size: | 180x260mm |
| Pages: | 309 |
| Weight: | .828 Kg. |
| Published: | Nova Science Publishers - November 2007 |
| List Price: | 59.5 Pounds Sterling |
| Availability: | In Print |
| Subjects: | Proteins |
In the recent years studies based on two-hybrid screens, proteomic, biochemical and cell biology approaches, have shown that intracellular domains of G protein-coupled receptors (GPCR) or heptaspanning membrane receptors (HSMRs) interact with intracellular proteins. These interactions are the basis of a protein network associated to these receptors which includes scaffolding proteins containing one or several PDZ (post-synaptic density-95, discs large, zona occludens-1) domains, signalling proteins and proteins of the cytoskeleton. The present book is focused on the emerging evidence for interactions of G protein-coupled receptors with scaffolding, cytoskeletal and signalling proteins that will play a role in the targeting, anchoring and functioning of these receptors in the plasma membrane, thus contributing to cell development and plasticity.
Adenosine Receptors Interacting Proteins (ARIPs); Adrenoceptors and their G Protein-Coupled Receptor Interacting Proteins (GIPS): Roles in Receptor Signalling and Regulation; 5-HT Receptor Interacting Proteins: from Fine-Tuning of Signalling to Novel Therapeutic Targets in Psychiatric Diseases; Muscarinic Receptor-Associated Proteins: More than just an Interaction between Proteins; Protein Interactions in Dopamine Receptor Signalling: From Receptor Complexes to Brain Disease; Novel Interacting Partners Regulating Opioid Receptor Signalling; Molecular Determinants Governing Protein-Protein Interactions with the Parathyroid Hormone I Receptor; GABAB Receptor-Associated Proteins: Understanding the Mechanisms of the GABAB Receptor Signalling; Binding Partners of Metabotropic Glutamate Receptors; Index.
