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MEDICINE


COUMARIN ANTICOAGULANT RESEARCH PROGRESS [Joseph P Edardes (ed)] Warfarin (also known under the brand names of Coumadin, Jantoven, Marevan, and Waran) is an anticoagulant medication that is administered orally or, very rarely, by injection. It is used for the prophylaxis of thrombosis and embolism in many disorders. Its activity has to be monitored by frequent blood testing for the international normalised ratio (INR). It is named for the Wisconsin Alumni Research Foundation. Warfarin is a synthetic derivative of coumarin, a chemical found naturally in many plants, notably woodruff (Galium odoratum, Rubiaceae), and at lower levels in liquorice, lavender and various other species. Warfarin was originally developed as a rat poison; however, more modern poisons are much more potent and toxic (e.g., brodifacoum). Warfarin and contemporary rodenticides belong to the same class of drugs (coumarins) and both decrease blood coagulation by interfering with vitamin K metabolism. For this reason, drugs in this class are also referred to as vitamin K antagonists. { 160pp, 180x260mm, February 2008; HB, £104.50, 160021990X:9781600219900 , Nova Science (Nova Biomedical) }
EXERCISE & HEALTH RESEARCH [Magnus D Johansen (ed)] In the last 50 years significant numbers of men and women take little exercise in the course of their occupation. The computer keyboard, the rise of private transport, the world by television, household 'labour saving' devices mean that with the minimal of physical effort people work and play. The benefits of doing regular exercise include a reduced risk of: heart disease, stroke, bowel cancer, breast cancer, osteoporosis, and obesity. In addition, many people feel better in themselves during and after exercise. Regular exercise is also thought to help ease stress, anxiety, and mild depression. This new book presents recent significant research from around the world dealing with various aspects and impacts of exercise as related to health. { March 2008; HB, £55.99, 1600219853:9781600219856 , Nova Science (Nova Biomedical) }
EXERCISE & WOMEN'S HEALTH : New Research [Laura T Allerton & Gloria P Rutherfode (eds)] In the last 50 years significant numbers of men and women take little exercise in the course of their occupation. Computer keyboard, rise of private transport, world by television, household "labour saving" devices, mean that people work and play with a minimal physical effort. The benefits of doing regular exercise include a reduced risk of heart disease, stroke, colon cancer, breast cancer, osteoporosis, and obesity. In addition, many people feel better about themselves during and after exercise. Regular exercise is also thought to help ease stress, anxiety, and mild depression. This book presents the latest research in this field. { May 2008; HB, £104.50, 1604561823:9781604561821 , Nova Science }
EXTENDED MATCHING QUESTIONS IN OPTHALMOLOGY [Tariq Ayoub iBSc MB BS Sharmin Badiei iBSc; Edited by Alexander Ionides MD BS FRCOphth MD] This book is a question book that focuses on ophthalmology and specialities related to ophthalmology including neurology, neurosurgery, ENT, infectious diseases, rheumatology, etc. Nearly all medical schools within the UK are now using extended matching questions (EMQ) to examine students on their knowledge of different specialities. This book is designed to give students the opportunity to hone their skills in answering such questions and will have approximately 150 EMQs relating to the following topics: Cornea and external eye disease; Cataract; Glaucoma; Medical retina and vitreo-retinal surgery; Strabismus; Paediatric ophthalmology; Neuro-ophthalmology; Ocular adnexal and orbital disease; Refractive errors and optics. There will be questions on diagnosis, investigation and management of different diseases. At the end of each section the answer to the questions and an explanation of the answer will also be given. This will help overall understanding and comprehension. { 300pp, 215x280mm, April 2008; PB, £25.00, 1903378583:9781903378588 , TFM Publishing }
FETAL CARDIOLOGY SIMPLIFIED : A Practical Manual [Gurleen Sharland, BS, MD, FRCP (ed)] Foetal cardiology has developed dramatically into a subspecialty in the past 25 years. The majority of people examining the foetal heart are not 'experts' in foetal cardiology and therefore find interpreting images, particularly in case of abnormality, rather difficult. This book is designed as a practical guide, to be kept near the ultrasound machine, for all those performing foetal heart scans, but without the expertise of a foetal cardiologist. The aim is to allow the user to recognise the common forms of foetal cardiac abnormality and to appreciate the associated lesions and outcome. The book has a large number of illustrations to enable the reader to visualise the different types of problem and the various forms in which they may manifest. There are relatively few books published in the field of foetal cardiology. Whilst there is a place for large textbooks covering all aspects of foetal cardiology in detail, most people performing the foetal heart scan need an idiot's guide about the normal foetal heart and the common things that go wrong with it. This book is aimed at all sonographers, obstetricians and radiologists performing obstetric ultrasound scans and at paediatric cardiologists, both at consultant and trainee level. Thus, this book should fulfil this unmet need in the market, although it is not designed as a comprehensive reference textbook in foetal cardiology. { 300pp, 210x270mm, May 2008; PB, £60.00, 1903378559:9781903378557 , TFM Publishing }
FLORENCE NIGHTINGALE -- THE NIGHTINGALE SCHOOL ((Collected Works of Florence Nightingale, Volume 12, Part One)) [Lynn McDonald (ed)] The 'Collected Works of Florence Nightingale' series demonstrates Nightingale's astute use of the political process and report on her extensive correspondence with royalty, viceroys, cabinet ministers and international leaders, including such notables as Queen Victoria and W E Gladstone. It will also contain a great deal of new material on family relations. Sixteen printed volumes are scheduled and will record her enormous and largely unpublished correspondence, previously published books, articles and pamphlets, many of which have long been out of print. There will be full publication in electronic form, permitting readers to easily pursue their particular interests. Extensive databases, notably a chronology and a names index, will also be published in electronic form, again permitting convenient access to persons interested not only in Nightingale but in other figures of the time. The series will confirm Nightingale as an important and significant nineteenth-century scholar and illustrate how she integrated her scholarship with political activism. Indispensable to scholars, and accessible and revealing to the general reader, it will show there is much more to know about Florence Nightingale than the 'lady with the lamp'. { 155x230mm, June 2008; HB, £81.99, 0889204675:9780889204676 , Wilfrid Laurier University Press }
FORENSIC PSYCHIATRY RESEARCH TRENDS [Raymond C Browne (ed)] Forensic psychiatry is a branch of medicine which focuses on the interface of law and mental health. It includes psychiatric consultation in a wide variety of legal matters (including expert testimony), as well as clinical work with perpetrators and victims. This book presents new and important research in the field. { March 2008; HB, £55.99, 1600219861:9781600219863 , Nova Science (Nova Biomedical) }
FUTURE BIOETHICS : Overcoming Taboos, Myths & Dogmas [Ronald A Lindsay] Few areas of public policy have been fraught with as much controversy as bioethics. Each novel development in biomedical technology seems to spark rancorous disputes. Those averse to new technologies often express the concern that the new technology is "unnatural" or requires us to "play God". Slogans such as "Frankenfoods" and "sanctity of life" substitute for reasoned argument. This is an ambitious book that seeks to reframe the debates surrounding current controversies in bioethics. Carefully examining and dissecting claims made by many policy-makers and ethicists on topics such as assistance in dying, genetic engineering, and embryonic stem cell research, bioethicist Ronald A Lindsay shows that all too often these claims are based on instinctive reactions, beliefs that lack factual support, and religious or ideological dogma. After describing in detail the proper way to approach and resolve a dispute in bioethics, Lindsay proceeds to analyse several different cutting-edge issues. Through his insightful analysis, Lindsay demonstrates how to achieve pragmatic, progressive solutions to these controversies. An antidote for misguided thinking, "Future Bioethics" illuminates the way forward to bioethics policies appropriate for the 21st century. { 340pp, 155x230mm, June 2008; HB, £20.99, 1591026245:9781591026242 , Prometheus Books }
HEMATOPOIETIC STEM CELL TRANSPLANTATION RESEARCH ADVANCES [Karl B Neumann (ed)] Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (that is, bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of haematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer. Stem cell transplantation was pioneered using bone-marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognised with a Nobel Prize in Physiology and Medicine. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called Graft-versus-host disease. With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoeitic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anaesthesia to collect the graft. Hematopoeitic stem cell transplantation remains a risky procedure with many possible complications; it has always been reserved for patients with life-threatening diseases. This book presents recent leading research in the field. { March 2008; HB, £104.50, 1604560428:9781604560428 , Nova Science (Nova Biomedical) }
IMMUNE TOLERANCE RESEARCH DEVELOPMENTS [Emile B Pontell (ed)] Immune or immunological tolerance is the process by which the immune system does not attack an antigen. It occurs in three forms: central tolerance, peripheral tolerance and acquired tolerance. Central tolerance is immunological tolerance developed during T and B cell differentiation. Peripheral tolerance is immunological tolerance developed after T and B cells mature and enter the periphery. Acquired or induced tolerance is the immune system's tolerance for external antigens. This book presents the latest research from around the world. { May 2008; HB, £104.50, 1604562099:9781604562095 , Nova Science }
LIVING WILL, LIVING WELL : Reflections on Preparing an Advance Directive [M Dianne Godkin] Using the voices of ordinary people, clinical ethicist and nurse Dianne Godkin explores the end-of-life issues and emotions that arise when an individual sets out to prepare an advance directive (living will). Conversations with study participants, and the composite character of Alice, are forthright, practical, and uplifting. Written for individuals and their families who are thinking about creating an advance directive, and for healthcare providers who interact with these individuals, this book provides readers with a deeper understanding of the experience of preparing for the end of life. { 288pp, 155x230mm, June 2008; PB, £13.99, 0888644949:9780888644947 , University of Alberta Press }
MADNESS IN BUENOS AIRES "Madness in Buenos Aires" examines the interactions between psychiatrists, patients and their families, and the national state in modern Argentina. This book offers a fresh interpretation of the Argentine state’s relationship to modernity and social change during the twentieth century, while also examining the often contentious place of psychiatry in modern Argentina. Drawing on a number of previously unused archival sources, author Jonathan Ablard demonstrates how the experience of psychiatric patients serves as a useful case study of how the Argentine state developed and functioned over the last century and of how Argentines interacted with it. Ablard argues that the capacity of the Argentine state to provide social services and professional opportunities and to control the populace was often constrained to an extent not previously recognised in the scholarly literature. These limitations, including a shortage of hospitals, insufficient budgets, and political and economic instability, shaped the experiences of patients, their families, and doctors and also influenced medical and lay ideas about the nature and significance of mental illness. Furthermore, these experiences, and the institutional framework in which they were imbedded, had a profound impact on how Argentine psychiatrists discussed not only mental illness, but also a host of related themes including immigration, poverty, and the role of the state in mitigating social problems. { May 2008; PB, £19.50, 1552382338:9781552382332 , University of Calgary Press }
MOTOR NEURON DISEASE RESEARCH PROGRESS [Raffaele L Mancini (ed)] The motor neuron diseases (or motor neuron diseases) (MND) are a group of progressive neurological disorders that destroy motor neurons, the cells that control voluntary muscle activity such as speaking, walking, breathing, and swallowing. Neurological examination presents specific signs associated with upper and lower motor neuron degeneration. Signs of upper motor neuron damage include spasticity, brisk reflexes and the Babinski sign. Signs of lower motor neuron damage include weakness and muscle atrophy. Every muscle group in the body requires both upper and lower motor neurons to function. It is a common misconception that "upper" motor neurons control the arms, while "lower" motor neurons control the legs. The signs described above can occur in any muscle group, including the arms, legs, torso, and bulbar region. Symptoms usually present between the ages of 50-70, and include progressive weakness, muscle wasting, and muscle fasciculations; spasticity or stiffness in the arms and legs; and overactive tendon reflexes. Patients may present with symptoms as diverse as a dragging foot, unilateral muscle wasting in the hands, or slurred speech. This new book presents the latest research from around the globe. { May 2008; HB, £104.50, 1604561556:9781604561555 , Nova Science }
NEW PERSPECTIVES ON KNOWLEDGE, ATTITUDES & PRACTICES IN HEALTH [Raymond W Pierce & Rebecca I Schwartz (eds)] This book focuses on new research in understanding knowledge, attitudes and practices in health around the globe. Advances in medicine as well as computers and electronics have made possible remarkable gains in our understanding of diseases on all levels from the theoretical to the clinical. In addition, much of the population can instantly access many types of health knowledge online. Blending the old and new knowledge and getting it public under relentless attack from their own insurance companies and seeing doctors under non-stop pressure to see more patients and order less tests, have created a situation where an understanding or health knowledge by many is essential yet often worse than the ailment. { March 2008; HB, £104.50, 1604560363:9781604560367 , Nova Science (Nova Biomedical) }
NEW RESEARCH ON AUTOANTIBODIES [Claude T Petrelli (ed)] Autoantibodies are a group of antibodies (immune proteins) that mistakenly target and damage specific tissues or organs of the body. One or more autoantibodies may be produced by a person's immune system when it fails to distinguish between "self" and "non-self" proteins. Usually the immune system is able to discriminate by recognising foreign substances (non-self) and ignoring the body's own cells (self), yet not overreact to non-threatening substances such as foods, dust and pollen, or beneficial microorganisms. It creates antibodies only when it perceives what it has been exposed to as a threat (non-self). When the immune system ceases to recognise one or more of the body's normal constituents as "self", it may produce autoantibodies that attack its own cells, tissues, and/or organs, causing inflammation and damage. The causes of this inappropriate action are varied and are not well understood, often resulting in a chronic auto-immune disorder. While there is not a direct link, it is thought that many cases of autoantibody production are due to a genetic predisposition combined with an environmental trigger (such as a viral illness or a prolonged exposure to certain toxic chemicals). Some families have been shown to have a high prevalence of auto-immune conditions; however, individual family members may have different auto-immune disorders or may never develop an auto-immune condition. Researchers believe that there may also be a hormonal component to the cause as many of the auto-immune conditions are more common in women of childbearing age. This book presents leading research from throughout the world. { March 2008; HB, £104.50, 160456055X:9781604560558 , Nova Science (Nova Biomedical) }
OSTEOARTHRITIS : Preventing & Healing without Drugs [Peter Bales, MD, MHSA] Osteoarthritis affects over 20 million Americans and is the most common degenerative disorder in the United States. it causes more disability than any other degenerative disease and is occurring in epidemic proportions throughout the world. In this novel approach to understanding and treating osteoarthritis, orthopaedic surgeon Peter Bales highlights the nutritional connection to this painful and debilitating condition, Dr Bales focuses on new genetic research, which shows that the same poor nutrition responsible for causing increased inflammation in our bodies, along with epidemic rates of obesity, diabetes, and heart disease, is also fuelling the development of osteoarthritis. Among the topics discussed are the following: the mechanisms by which our joints become destroyed. The culprits are increased inflammation, increased oxygen free radicals causing our joints to "rust" from chronically elevated blood sugar levels and hormone imbalance. Dietary strategies to decrease the production of oxygen free radicals, and to turn off genes that lead to cartilage breakdown. Joint nutrients that can combat osteoarthritis and specific dietary recommendations for the treatment and reversal of osteoarthritis based on the more current genetic and nutritional research. The disadvantages of treating osteoarthritis with drugs and the exciting promise of using nutritional intervention that directly affects the expression of our genes. The only book to emphasise the link between poor nutrition and osteoarthritis, this important new approach to an often disabling disease offers hope for arthritis sufferers and will be of interest to anyone concerned about good health. { 250pp, 155x230mm, May 2008; PB, £13.99, 1591026156:9781591026150 , Prometheus Books }
PAIN RESEARCH PROGRESS : Migraine, Fibromyalia & Related Pain [Fengrui Hu (ed)] Pain is an unpleasant sensation. It is defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage". Pain is part of the body's defence system: it triggers mental problem-solving strategies that seek to end the painful experience, and it promotes learning, making repetition of the painful situation less likely. The nociceptive system transmits signals that usually trigger the sensation of pain, it is a critical component of the body's ability to react to damaging stimuli and it is part of a rapid-warning relay instructing the central nervous system to initiate reactions for minimising injury. This book presents the latest research in the field from around the globe. { March 2008; HB, £104.50, 160021679X:9781600216794 , Nova Science (Nova Biomedical) }
PREVENTION OF CANCER : New Research [Joel W Rosenthal & William J Carey (eds)] This book presents the latest research on advances in genetics, molecular medicine, biotechnologies, and behavioural sciences that have an impact on primary, secondary and tertiary cancer prevention including: (a) Basic mechanisms of neoplastic diseases leading to the identification of molecular pathways that can be employed as targets for cancer prevention; (b) Descriptive, analytical, and molecular epidemiology with emphasis on developing biomarkers of cancer risk assessment and response to cancer prevention; (c) Laboratory and clinical procedures for prognostic evaluation of malignant tumour transformation, progression and response to treatment with cancer preventive agents; (d) Discoveries of natural substances and synthetic agents that have promising cancer preventive potential and elucidating their mechanistic action; (e) Development and assessment of cancer preventive approaches that have potential for being translated into the clinic; (f) Cancer prevention pre-clinical studies and clinical trials; (g) Patient management and education, management of curable lesions, education and lifestyle modification and the role of behavioural factors in cancer etiology and prevention. { May 2008; HB, £104.50, 1604562293:9781604562293 , Nova Science }
PSYCHOLOGICAL COUNSELING RESEARCH FOCUS [James A Patterson & Irina N Lipschitz (eds)] Counselling psychology as a psychological speciality facilitates personal and interpersonal functioning across the life span with a focus on emotional, social, vocational, educational, health-related, developmental, and organisational concerns. Through the integration of theory, research, and practice, and with a sensitivity to multicultural issues, this speciality encompasses a broad range of practices that help people improve their well-being, alleviate distress and maladjustment, resolve crises, and increase their ability to live more highly functioning lives. Though closely related to clinical psychology, counselling psychology differs from that field in a several subtle ways. First, counselling psychologists typically focus on less severe psychopathology (e.g., depression and anxiety), while clinical psychologists deal with more seriously disturbed individuals (e.g., those with schizophrenia or personality disorders). Second, counselling psychologists are more likely than clinical psychologists to assume a client-centred or humanistic theoretical approach. Finally, counselling psychology is unique in its attention both to normal developmental issues as well as the problems associated with physical, emotional, and mental disorders. Despite these differences, counselling and clinical psychology are becoming increasingly indistinguishable, leading some to suggest that these fields be combined. Populations served by counselling psychologists include persons of all ages and cultural backgrounds. Examples of those populations would include late adolescents or adults with career/educational concerns and children or adults facing severe personal difficulties. Counselling psychologists also consult with organisations seeking to enhance their effectiveness or the well-being of their members. This book focuses on new research in the field from around the world. { March 2008; HB, £104.50, 160456041X:9781604560411 , Nova Science (Nova Biomedical) }
RESEARCH FOCUS ON SMOKING & WOMEN'S HEALTH [Katherine P Tolson & Emily B Veksler (eds)] The Office of the US Surgeon General, in detailed report entitled "Women and Smoking," made the following statement: "When calling attention to public health problems, we must not misuse the word 'epidemic.' But there is no better word to describe the 600-percent increase since 1950 in women's death rates for lung cancer, a disease primarily caused by cigarette smoking. Clearly, smoking-related disease among women is a full-blown epidemic." -- David Satcher, MD, PhD. Tobacco use accounts for nearly one third of all cancer deaths. Tens of thousands of women will die this year from lung cancer, which has greatly surpassed breast cancer as the leading cause of cancer death among women. More than 90% of these deaths will be due to smoking. In addition to increasing the risk for lung cancer, smoking is a risk factor for cancers of the cervix, mouth, larynx (voice box), pharynx (throat), oesophagus, kidney, bladder, pancreas, and stomach. It is also connected to some forms of leukaemia. This new book is dedicated to recent and important research from around the world. { May 2008; HB, £104.50, 1604561491:9781604561494 , Nova Science }
RESEARCH ON THE NEUROBIOLOGY OF ALCOHOL USE DISORDERS [Leo Sher] This book describes the neurobiological mechanisms of alcohol abuse and dependence including the role of serotonergeic, dopaminergic, noradrenergic, and hypothalamic-piturary adrenal systems in alcohol use disorders and the results of neuroimaging studies are presented. The neurobiology of comorbidity of alcohol use disorders with other psychiatric disorders are also discussed. Research on the neurobiology of alcohol abuse and dependence is very important. Therefore, this book will be of interest to biomedical researchers, physicians, and other clinicians, students, and anyone who is interested in the mechanisms of addictive disorders. { May 2008; HB, £63.99, 1604561971:9781604561975 , Nova Science }
RESEARCH PROGRESS IN ALZHEIMER'S DISEASE & DEMENTIA, VOLUME 3 ((Research Progress in Alzheimer's Disease and Dementia Series)) [Maio-Kun Sun (ed)] Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective treatments are developed. Since the publication of the second book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists worldwide. This third book volume contains 15 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics include molecular genetics of AD, gene expression abnormalities in AD progression, presenilins, taupathy in AD, single -induced(neuron gene expression abnormalities in AD, intracellular A neurodegeneration, roles of lipoprotein receptors in AD onset and progression, cholesterol and tau hyperphosphorylation, AD diagnostics and therapeutic strategies, in vivo visualisation of amyloid-like structures, cathepsin B, antiamyloidogenesis and neuroprotection, environmental enrichment, Fragile X mental retardation gene and dementia, category learning in Parkinson's disease, cerebrovascular disease and dementia, and dementia and hypertension. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in AD and dementia. { March 2008; HB, £104.50, 1600219608:9781600219603 , Nova Science (Nova Biomedical) }
RESEARCH TRENDS IN NUTRITION FOR THE MIDDLE AGED & ELDERLY [Johan P Urster (ed)] The ageing process changes body composition and thus nutritional status changes as one gets older. At the same time the body becomes more susceptible to diseases and diet becomes an even more significant or at least visibly significant than in earlier years. Moreover, there is frequently socio-economic downward drifting in this age group making nutritious foods more difficult to afford. This new book presents leading-edge research from around the world. { May 2008; HB, £104.50, 1604561475:9781604561470 , Nova Science }
T-CELL VACCINATION [Jingwu Zhang & Irun R Cohen (eds)] This book provides a comprehensive review of T cell vaccination which is a topic of significant interest in the field of Immunology. However, its academic value is not limited to basic research into the understanding of autoimmune T cell regulation in vivo, for the research is supported by preliminary clinical application. Indeed, T cell vaccinations have been tested in a number of promising clinical trials as a potential treatment for human auto-immune disease. T cell vaccination has thus evolved as one of the most interesting topics of immunology and translational medicine. { May 2008; HB, £63.99, 1604561785:9781604561784 , Nova Science }
URINARY TRACT INFECTIONS : Questions & Answers [Abhay Rane] This state-of-the art publication covers pathophysiology of UTI, risk factors, complicated and non-complicated UTIs. Text includes: UTIs in women (including the difficult issue of UTI in pregnancy); UTIs in the elderly and children are given separate credence in individual subsections; Clinical investigations carried out are discussed and the rationale for each explained; Mechanism of action, dose schedule and efficacy of commonly used antibacterials are discussed to allow for easy and appropriate decisions to be taken. { 145pp, 160x240mm, April 2008; PB, £24.95, 1873413432:9781873413432 , Merit Publishing }